Why do taste cells generate action potentials?
نویسندگان
چکیده
Taste cells regularly generate action potentials, but their functional significance in taste signaling is unclear. A paper in BMC Neuroscience reveals the identity of the voltage-gated Na+ channels underlying action potentials, providing the foundation for insights into their function.
منابع مشابه
Minireview Why do taste cells generate action potentials ?
More than two decades ago, Steve Roper first reported that the large taste cells of the aquatic salamander Necturus are electrically excitable and generate action potentials in response to membrane depolarization [1]. It is now well documented that the taste cells of most, if not all, vertebrate species regularly generate action potentials not only on electrical stimulation, but also in respons...
متن کاملTaste responsiveness of fungiform taste cells with action potentials.
It is known that a subset of taste cells generate action potentials in response to taste stimuli. However, responsiveness of these cells to particular tastants remains unknown. In the present study, by using a newly developed extracellular recording technique, we recorded action potentials from the basolateral membrane of single receptor cells in response to taste stimuli applied apically to ta...
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Only some taste cells fire action potentials in response to sapid stimuli. Type II taste cells express many taste transduction molecules but lack well-elaborated synapses, bringing into question the functional significance of action potentials in these cells. We examined the dependence of adenosine triphosphate (ATP) transmitter release from taste cells on action potentials. To identify type II...
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Taste receptor cells fire action potentials in response to taste substances to trigger non-exocytotic neurotransmitter release in type II cells and exocytotic release in type III cells. We investigated possible differences between these action potentials fired by mouse taste receptor cells using in situ whole-cell recordings, and subsequently we identified their cell types immunologically with ...
متن کاملThe K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction.
Sour taste is detected by a subset of taste cells on the tongue and palate epithelium that respond to acids with trains of action potentials. Entry of protons through a Zn(2+)-sensitive proton conductance that is specific to sour taste cells has been shown to be the initial event in sour taste transduction. Whether this conductance acts in concert with other channels sensitive to changes in int...
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عنوان ژورنال:
- Journal of Biology
دوره 8 شماره
صفحات -
تاریخ انتشار 2009